Endocrine Abstracts

Introduction: Male hypogonadism may complicate Addison’s disease (AD), but the prevalence of testosterone deficiency in adult males with primary hypoadrenalism is unknown.Methods: Male patients older than 18 years of age enrolled in the South African AD national registry were screened for biochemical testosterone deficiency (early morning basal testosterone <9.9 nmol/l). Testing was also performed to see if these subjects were more susceptible t...

Background: Salivary cortisol, as measured using electro-chemiluminescence has been used to monitor patients with Addison’s disease (AD) on hydrocortisone replacement. Salivary cortisone has been suggested as an alternative to salivary cortisol, as it may accurately reflect plasma free cortisol. We wished to examine the pharmacokinetics of these analytes in patients and controls.Methods: We measured salivary cortisol and salivary cortisone by liquid...